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Article

Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy

14 Jun 2021

Abstract excerpt

Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and stability. Here, we investigated the characteristics of SETD2 somatic mutation in the cancer genome atlas pan-cancer cohort. Our data revealed that, compared with SETD2 nonmutant patients, SETD2 mutant patients had higher tumor mutation burden and microsatellite instability. In addition, the transcriptions of most genes...

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PMID: 34127768
DOI: 10.1038/s41698-021-00193-0

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