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Article

Epigenetic gene alterations in metastatic solid tumours: results from the prospective precision medicine MOSCATO and MATCH-R trials.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2022

Martin-Romano Patricia, Colmet-Daage Leo, Morel Daphne, Baldini Capucine, Verlingue Loic, Bahleda Rastilav, Gazzah Anas, Champiat Stephan, Varga Andree, Michot Jean Marie, Ngo-Camus Maud, Nicotra Claudio, Marabelle Aurelien, Soria Jean Charles, Rouleau Etienne, Lacroix Ludovic, Hollebecque Antoine, Massard Christophe, Postel-Vinay Sophie

Abstract excerpt

INTRODUCTION: Although the role of epigenetic alterations in oncogenesis has been well studied, their prevalence in metastatic solid tumours is still poorly described. We therefore aimed at: (i) describing the presence of epigenetic gene alterations (EGA) - defined by an alteration in a gene encoding an epigenetic regulator; and (ii) evaluating their relationship with clinical characteristics and outcome in...

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Identifiers

PMID: 35872509
DOI: 10.1016/j.ejca.2022.06.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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