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Article

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.

Oncotarget - 10 Feb 2015

Liu Lanxin, Kimball Sarah, Liu Hui, Holowatyj Andreana, Yang Zeng-Quan

Abstract excerpt

Histone lysine methyltransferases (HMTs), a large class of enzymes that catalyze site-specific methylation of lysine residues on histones and other proteins, play critical roles in controlling transcription, chromatin architecture, and cellular differentiation. However, the genomic landscape and clinical significance of HMTs in breast cancer remain poorly characterized. Here, we conducted a meta-analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25537518
DOI: 10.18632/oncotarget.2967
PMCID: PMC4385864

Genes

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SETDB2
SMYD2
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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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