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Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers

2 Mar 2021

Abstract excerpt

Immune checkpoint therapy (ICT) can produce durable antitumor responses in various cancer types; however, the responses are not universal, and the predictive biomarkers are urgently needed. Growing evidence points to a link between epigenetic regulation and anti-tumor immunity, while clinical data on the association of genomic alterations in transcriptional dysregulation-related genes and ICT clinical benefit are...

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PMID: 33653367
DOI: 10.1186/s13045-021-01050-0

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