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Article

KMT2C and KMT2D aberrations in breast cancer.

Trends in cancer - 1 Jun 2024

Tinsley Emily, Bredin Philip, Toomey Sinead, Hennessy Bryan T, Furney Simon J

Abstract excerpt

KMT2C and KMT2D are histone lysine methyltransferases responsible for the monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D are the most frequently mutated histone methyltransferases (HMTs) in breast cancer, occurring at frequencies of 10-20% collectively. Frequent damaging and truncating somatic mutations indicate a tumour-suppressive role of KMT2C/D in breast oncogenesis....

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38453563
DOI: 10.1016/j.trecan.2024.02.003

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