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Article

Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Dec 2011

Ware Jennifer J, van den Bree Marianne B M, Munafò Marcus R

Abstract excerpt

INTRODUCTION: Variation in the CHRNA5-A3-B4 gene cluster is a promising candidate region for smoking behavior and has been linked to multiple smoking-related phenotypes (e.g., nicotine dependence) and diseases (e.g., lung cancer). Two single nucleotide polymorphisms (SNPs), rs16969968 in CHRNA5 and rs1051730 in CHRNA3, have generated particular interest. METHODS: We evaluated the published evidence for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22071378
DOI: 10.1093/ntr/ntr118
PMCID: PMC3223575

Genes

CHRNA5
CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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