Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content.

doi:10.1038/tpj.2012.50

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Article

Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content.

The pharmacogenomics journal - 1 Feb 2014

Macqueen D A, Heckman B W, Blank M D, Janse Van Rensburg K, Park J Y, Drobes D J, Evans D E

Abstract excerpt

A single-nucleotide polymorphism (SNP) in the α5 nicotinic acetylcholine receptor subunit gene, rs16969968, has been repeatedly associated with both smoking and respiratory health phenotypes. However, there remains considerable debate as to whether associations with lung cancer are mediated through effects on smoking behavior. Preclinical studies suggest that α5 receptor subunit expression and function may have a...

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Identifiers

PMID: 23358500
DOI: 10.1038/tpj.2012.50
PMCID: PMC3778124

Genes

CHRNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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