Article

SARS-CoV-2 Nsp15 Suppresses Type I Interferon Production by Inhibiting IRF3 Phosphorylation And Nuclear Translocation

2023-02-03

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused 2019 coronavirus disease (COVID-19) poses a serious threat to global public health security. SARS-CoV-2, like other coronaviruses, has evolved many strategies to inhibit interferon (IFN) production. Here, we identify that SARS-CoV-2 Nsp15 suppresses IFN production by antagonizing the RLR-mediated antiviral signaling pathway. Overexpressed Nsp15 ob...

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Literature Corpus work: d158a9fa-5136-5131-a3ff-1ebbdd8e287c
DOI: 10.2139/ssrn.4345044

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