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Article

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation.

Cellular & molecular immunology - 1 Apr 2021

Wang Wenjing, Zhou Zhuo, Xiao Xia, Tian Zhongqin, Dong Xiaojing, Wang Conghui, Li Li, Ren Lili, Lei Xiaobo, Xiang Zichun, Wang Jianwei

Abstract excerpt

SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor inducer of type I interferon (IFN). Here, we report that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses. SARS-CoV-2 nsp12 attenuated Sendai virus (SeV)- or poly(I:C)-induced IFN-β promoter activation...

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Identifiers

PMID: 33637958
DOI: 10.1038/s41423-020-00619-y
PMCID: PMC7907794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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