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SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

3 Apr 2024

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of deaths since its emergence in 2019. Innate immune antagonism by lethal CoVs such as SARS-CoV-2 is crucial for optimal replication and pathogenesis. The conserved nonstructural protein 15 (nsp15) endoribonuclease (EndoU) limits activation of double-stranded (ds)RNA-induced pathways, including interferon (IFN) signaling, protein...

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PMID: 38568967
DOI: 10.1073/pnas.2320194121

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