Article
Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.
PLoS biology - 1 May 2026
Zhou Fuchun, Periasamy Sivakumar, Jackson Nathaniel D, Cheng Wan Sze, Soto Acosta Ruben, Tripathi Aarti, Kedarinath Kritika, Ilinykh Philipp A, Ye Chengjin, Chauhan Shailendra, Nudelman German, Zaslavsky Elena, Hao Haiping, Widen Steven G, Martinez-Sobrido Luis, Sealfon Stuart C, Bukreyev Alexander
Abstract excerpt
Several SARS-CoV-2 proteins have been shown to counteract the host innate immune response, mostly using in vitro protein expression, which may not fully reflect their role in the context of viral infection. In addition, while each viral protein was characterized in a different experimental system, its relative contribution to immunosuppression remains unclear. Here we used a SARS-CoV-2 bacterial artificial...
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