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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses

2024-09-05

Abstract excerpt

Coronavirus (CoV) Nsp15 is a viral endoribonuclease (EndoU) with a preference for uridine residues. CoV Nsp15 is an innate immune antagonist which prevents dsRNA sensor recognition and stress granule formation by targeting viral and host RNAs. SARS-CoV-2 restricts and delays the host antiviral innate immune responses through multiple viral proteins, but the role of SARS-CoV-2 Nsp15 in innate immune evasion is not...

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Identifiers and source

Literature Corpus work
2e964211-a6e4-58ab-bfcc-77516b07599c
DOI
10.1101/2024.09.05.611469
Open publication

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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responsesDOI 10.1101/2024.09.05.611469
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