Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cells

21 Aug 2025

Abstract excerpt

ABSTRACT Coronaviruses encode nonstructural protein 15 (Nsp15), a conserved endoribonuclease (EndoU) known to suppress host antiviral responses. It is imperative to understand the role of Nsp15/EndoU during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in its primary target respiratory epithelial cells. Using a recombinant wild-type SARS-CoV-2 (rWT) and a mutant with catalytically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40838727
DOI: 10.1128/jvi.01175-25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cellsPMID 40838727Read ↗

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signalingSemantic proximity Read ↗

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responsesSemantic proximity Read ↗

SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses.Semantic proximity Read ↗

Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathwaysSemantic proximity Read ↗

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cellsSemantic proximity Read ↗

Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infectionSemantic proximity Read ↗

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read ↗

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity Read ↗

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsSemantic proximity Read ↗

The Role of Coronavirus RNA-Processing Enzymes in Innate Immune EvasionSemantic proximity Read ↗

Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome CoronavirusSemantic proximity Read ↗

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.