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Corticospinal propagation of full-length TDP-43 toxicity drives brain-to-muscle pathology

2026-08-26

Abstract excerpt

<title>Abstract</title> <p> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive degeneration of upper and lower motor neurons. Cytoplasmic inclusions containing TAR DNA-binding protein 43 (TDP-43) represent a pathological hallmark of all sporadic (sALS) and most familial (fALS) forms, underscoring its central role in disease pathophysiology. In affected neurons,...

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Literature Corpus work: d155b0c3-bb5d-5a69-9acd-b4d10ced8d1e
DOI: 10.21203/rs.3.rs-10681556/v1

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