Mechanisms of TDP-43 Proteinopathy Onset and Propagation.

Abstract excerpt

TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a number of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. While mutations in the TARDBP gene that codes for the protein have been identified as causing disease in a small subset of patients, TDP-43 proteinopathy is present in the majority of cases regardless of mutation status....

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• Amyotrophic Lateral Sclerosis
• Amyotrophic Lateral Sclerosis Research
• DNA-Binding Proteins
• Frontotemporal Dementia
• Mutation