Article

Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis

2023-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease mostly affecting people around 50-60 years of age. TDP-43, a ubiquitously expressed RNA-binding protein involved in pre-mRNA splicing and controlling mRNA stability and translation, forms neuronal cytoplasmic inclusions in an overwhelming majority of ALS patients, of both sporadic and familial origin, a phenom...

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Literature Corpus work: 65f52793-d86c-5216-97e1-fa656010eb90
DOI: 10.1101/2023.05.17.540919

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