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Article

The basis of clinicopathological heterogeneity in TDP-43 proteinopathy

26 Sept 2019

Abstract excerpt

Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major disease-associated component in the brain of patients with amyotrophic lateral sclerosis (ALS), as well as the largest subset of patients with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), which characteristically exhibits cytoplasmic inclusions that are positive for ubiquitin but negative for tau and...

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PMID: 31555895
DOI: 10.1007/s00401-019-02077-x

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