Article

Skeletal muscle TDP-43 aggregation drives progressive motor dysfunction and neurodegeneration with potential for functional recovery after clearance

2025-07-23

Abstract excerpt

Understanding the mechanisms driving TDP-43 pathology is essential for combating amyotrophic lateral sclerosis and other neurodegenerative diseases. To investigate the contribution of skeletal muscle to disease onset, progression, and recovery, we generated an inducible, muscle-specific TDP-43 mouse model. Cytoplasmic aggregation of exgogenous human TDP-43 protein in skeletal muscle led to muscle dysfunction, dene...

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Literature Corpus work: f7c52277-cfd3-5649-8518-5e16bff0c235
DOI: 10.1101/2025.07.20.664544

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