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Article

What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review.

Translational neurodegeneration - 20 Sept 2026

Pasho Elena, Catanese Alberto, Kabashi Edor, Ciura Sorana

Abstract excerpt

The degenerating motor neurons of amyotrophic lateral sclerosis (ALS) patients are characterized by the accumulation of cytoplasmic aggregates, specifically enriched in ubiquitinated TDP-43. Expressed mainly in the nucleus and partially in the cytoplasm to execute its role in RNA metabolism, the exact mechanisms that bring TDP-43 to aggregate in disease have yet to be described. Unfolding these processes could...

Read the complete abstract on PubMed

Topics

Amyotrophic Lateral Sclerosis
Humans
Motor Neurons
Induced Pluripotent Stem Cells
DNA-Binding Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Source

Open in PubMed Open full text

Identifiers

PMID: 42764383
DOI: 10.1186/s40035-026-00580-2
PMCID: PMC13589874

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review.PMID 42764383Read ↗

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