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Article

TDP-43 proteinopathies: a new wave of neurodegenerative diseases

11 Nov 2020

Abstract excerpt

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For instance, the majority of patients with sporadic amyotrophic lateral sclerosis (up to 97%) and a substantial proportion of patients with frontotemporal lobar degeneration (~45%) exhibit TDP-43 positive neuronal...

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PMID: 33177049
DOI: 10.1136/jnnp-2020-322983

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