Article

Hepatic ketogenesis regulates lipid homeostasis via ACSL1-mediated fatty acid partitioning

2023-07-18

Abstract excerpt

<title>Abstract</title> <p>Liver-derived ketone bodies play a crucial role in fasting energy homeostasis by fueling the brain and peripheral tissues. Ketogenesis also acts as a conduit to remove excess acetyl-CoA generated from fatty acid oxidation and protects against diet-induced hepatic steatosis. Surprisingly, no study has examined the role of ketogenesis in fasting-associated hepatocellular lipid metabolism....

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Literature Corpus work: d1514f8d-2f90-5d7b-ae71-9db455d132e6
DOI: 10.21203/rs.3.rs-3147009/v1

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