Article

Sex- and ketogenesis-dependent effects of intermittent fasting against diet-induced obesity and fatty liver disease

2025-11-18

Abstract excerpt

<h4>ABSTRACTS</h4> Intermittent fasting (IF) improves metabolic health, yet the requirement for hepatic ketogenesis in mediating these benefits remains unclear. Here, we investigated how hepatic ketogenesis contributes to the metabolic and hepatic effects of IF in male and female mice. In the human liver, ketogenesis-associated genes showed sex-dependent correlations with inflammatory and fibrotic pathways. In mi...

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Identifiers and source

Literature Corpus work: 199c87dc-716e-57b5-b5ec-2007371f64cb
DOI: 10.1101/2025.11.17.688915

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