Article
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Cell metabolism - 5 Sept 2017
Simcox Judith, Geoghegan Gisela, Maschek John Alan, Bensard Claire L, Pasquali Marzia, Miao Ren, Lee Sanghoon, Jiang Lei, Huck Ian, Kershaw Erin E, Donato Anthony J, Apte Udayan, Longo Nicola, Rutter Jared, Schreiber Renate, Zechner Rudolf, Cox James, Villanueva Claudio J
Abstract excerpt
Cold-induced thermogenesis is an energy-demanding process that protects endotherms against a reduction in ambient temperature. Using non-targeted liquid chromatography-mass spectrometry-based lipidomics, we identified elevated levels of plasma acylcarnitines in response to the cold. We found that the liver undergoes a metabolic switch to provide fuel for brown fat thermogenesis by producing acylcarnitines. Cold...
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