Article

NRDE2 Interacts with an Early Transcription Elongation Complex and Widely Impacts Gene Expression

2025-08-24

Abstract excerpt

NRDE2 is a highly conserved protein implicated in post-transcriptional gene silencing in Schizosaccharomyces pombe and Caenorhabditis elegans and has been shown to modulate splicing in mammals. To explore whether NRDE2 participates in additional processes in human cells, we performed tandem affinity purification followed by proteomic analysis of NRDE2 from nuclear extracts of HEK293T and HeLa cells. Our analysis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d14652e3-65b0-5fbb-aa70-a75fdd37735c
DOI: 10.1101/2025.08.20.671253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NRDE2 Interacts with an Early Transcription Elongation Complex and Widely Impacts Gene ExpressionDOI 10.1101/2025.08.20.671253Read

A novel RNA-binding activity of ECD contributes to U5 snRNP stability and pre-mRNA splicingSemantic proximity Read

Comprehensive Identification of RNA-Binding Domains in Human Cells.Semantic proximity Read

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loopsSemantic proximity Read

Waking the sleepers: lincRNA overexpression compromises DHX36 activity and global protein synthesisSemantic proximity Read

High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleasesSemantic proximity Read

Exonuclease assisted mapping of protein-RNA interactions (ePRINT)Semantic proximity Read

The RNA binding protein Nab2 genetically interacts with multiple RNA exosome cofactors to regulate target RNAsSemantic proximity Read

A Large-Scale Binding and Functional Map of Human RNA Binding ProteinsSemantic proximity Read

Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.Semantic proximity Read

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read

The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway.Semantic proximity Read

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.Semantic proximity Read