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Article

Comprehensive Identification of RNA-Binding Domains in Human Cells.

Molecular cell - 18 Aug 2016

Castello Alfredo, Fischer Bernd, Frese Christian K, Horos Rastislav, Alleaume Anne-Marie, Foehr Sophia, Curk Tomaz, Krijgsveld Jeroen, Hentze Matthias W

Abstract excerpt

Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of these employing unknown modes of RNA binding. We developed RBDmap to determine the RNA-binding sites of native RBPs on a proteome-wide scale. We identified 1,174 binding sites within 529 HeLa cell RBPs, discovering numerous RNA-binding domains (RBDs). Catalytic centers or protein-protein interaction domains are in close...

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Identifiers

PMID: 27453046
DOI: 10.1016/j.molcel.2016.06.029
PMCID: PMC5003815

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