Article
Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.
Cell death & disease - 21 Jun 2021
Fütterer Agnes, Talavera-Gutiérrez Amaia, Pons Tirso, de Celis Jesús, Gutiérrez Julio, Domínguez Plaza Verónica, Martínez-A Carlos
Abstract excerpt
Embryonic stem cell (ESC) differentiation and somatic cell reprogramming are biological processes governed by antagonistic expression or repression of a largely common set of genes. Accurate regulation of gene expression is thus essential for both processes, and alterations in RNA processing are predicted to negatively affect both. We show that truncation of the DIDO gene alters RNA splicing and transcription...
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