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Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers

25 Jul 2025

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism observed in 15% of human cancers. A hallmark of ALT cancers is the presence of C-circles, circular single-stranded DNAs (ssDNAs) enriched with cytosine-rich telomere (C-rich, CCCTAA) sequences. G-circles, containing guanosine-rich telomere (G-rich, GGGTTA) ssDNAs, also exist but are much less abundant. Recent...

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Share to Advanced biosensing and bioanalysis techniques
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

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PMID: 40795958
DOI: 10.1093/nar/gkaf771

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