Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

Abstract excerpt

Telomerase-independent ALT (alternative lengthening of telomeres) cells are characterized by high frequency of telomeric homologous recombination (HR), C-rich extrachromosomal circles (C-circles) and C-rich terminal 5' overhangs (C-overhangs).However, underlying mechanism is poorly understood.Here, we show that both C-circle and C-overhang form when replication fork collapse is induced by strand break at...

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