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Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

18 Nov 2008

Abstract excerpt

A significant fraction of human cancer cells and immortalized cells maintain telomeres in a telomerase-independent manner called alternative lengthening of telomeres (ALT). It has been suggested that ALT involves homologous recombination that is expected to generate unique intermediate DNAs. However, the precise molecular mechanism of ALT is not known. To gain insight into how telomeric DNAs (T-DNAs) are...

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Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 19015236
DOI: 10.1128/mcb.00603-08

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