Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells

30 Mar 2023

Abstract excerpt

Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). Currently, the primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs). How C-circles form is not well characterized. We investigated C-circle formation in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37003504
DOI: 10.1016/j.jbc.2023.104665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cellsPMID 37003504Read ↗

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancersSemantic proximity Read ↗

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancersSemantic proximity Read ↗

Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanismsSemantic proximity Read ↗

Extrachromosomal telomere DNA derived from excessive strand displacementsSemantic proximity Read ↗

Extrachromosomal Telomeres Derived from Excessive Strand DisplacementsSemantic proximity Read ↗

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombinationSemantic proximity Read ↗

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cellsSemantic proximity Read ↗

Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized CellsSemantic proximity Read ↗

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.Semantic proximity Read ↗

A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissueSemantic proximity Read ↗

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.Semantic proximity Read ↗

Detection of alternative lengthening of telomeres by telomere quantitative PCRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.