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Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers

2025-04-19

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism observed in 15% of human cancers. A hallmark of ALT cancers is the presence of C-circles, circular single-stranded DNAs (ssDNAs) enriched with cytosine-rich telomere (C-rich, CCCTAA) sequences. G-circles, containing guanosine-rich telomere (G-rich, GGGTTA) ssDNAs, also exist but are much less abundant. Recent stud...

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Literature Corpus work
f2801e6d-e462-523d-9ab6-059b22dde6c4
DOI
10.1101/2025.04.15.648952
Open publication

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Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancersDOI 10.1101/2025.04.15.648952
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