Article

A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans.

2025-05-03

Abstract excerpt

The peripheral CD4+ T-cells with cytolytic potential (CD4-CTLs) have been detected in several diseases, including infectious diseases and various cancers. They form the component of protective immune response and are shown to be enriched in the effector memory expressing CD45RA (TEMRA) in humans. However, the lack of understanding about their lineage, molecular characters, and cytolytic potential in comparison to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d12b98dc-ab88-5d10-a4ad-8abc499fba2b
DOI: 10.1101/2025.04.29.651205

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans.DOI 10.1101/2025.04.29.651205Read

Progenitor effects and unique transcriptomic signatures linked to differentiation phenotype in clonally expanded antigen-specific CD8 T memory stem cells.Semantic proximity Read

Single-cell transcriptomic and TCR analysis of human Cytomegalovirus (hCMV)-specific memory T cells reveals effector and pre-effectors of CD8 + - and CD4 + -cytotoxic T cellsSemantic proximity Read

Single-cell transcriptomic and TCR analysis of human Cytomegalovirus (hCMV)-specific memory T cells reveals effector and pre-effectors of CD8 <sup>+</sup> - and CD4 <sup>+</sup> -cytotoxic T cellsSemantic proximity Read

Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4⁺CD8⁺ double-positive T cellsSemantic proximity Read

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell populationSemantic proximity Read

Single‐cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus ( hCMV )‐specific memory T cells reveals effectors and pre‐effectors of CD8 + ‐ and CD4 + ‐cytotoxic T cellsSemantic proximity Read

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenariansSemantic proximity Read

A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses.Semantic proximity Read

Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolboxSemantic proximity Read

Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses.Semantic proximity Read

The Era of Cytotoxic CD4 T CellsSemantic proximity Read

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancerSemantic proximity Read