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Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses.

Frontiers in immunology - 1 Jan 2022

Kawabe Takeshi, Ciucci Thomas, Kim Kwang Soon, Tayama Shunichi, Kawajiri Akihisa, Suzuki Takumi, Tanaka Riou, Ishii Naoto, Jankovic Dragana, Zhu Jinfang, Sprent Jonathan, Bosselut Rémy, Sher Alan

Abstract excerpt

Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulations of explicit foreign antigen (Ag)-specific "authentic" memory and foreign Ag-independent memory-phenotype (MP) cells, phenotypic markers differentially expressed in...

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PMID: 35707543
DOI: 10.3389/fimmu.2022.870542
PMCID: PMC9190281

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