Single‐cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus ( hCMV )‐specific memory T cells reveals effectors and pre‐effectors of CD8 + ‐ and CD4 + ‐cytotoxic T cells

Abstract excerpt

Abstract Latent human cytomegalovirus (hCMV) infection can pose a serious threat of reactivation and disease occurrence in immune‐compromised individuals. Although T cells are at the core of the protective immune response to hCMV infection, a detailed characterization of different T cell subsets involved in hCMV immunity is lacking. Here, in an unbiased manner, we characterized over 8000 hCMV‐reactive peripheral...

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• Cytomegalovirus and herpesvirus research
• Immune Cell Function and Interaction
• Neuroinflammation and Neurodegeneration Mechanisms