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Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

26 Feb 2021

Abstract excerpt

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human cancers, resembling CD8 T cell profiles. Using the peptide-MHCII-multimer technology, we confirmed ex vivo the...

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PMID: 33637530
DOI: 10.1126/sciadv.abe3348

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