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Article

Progenitor effects and unique transcriptomic signatures linked to differentiation phenotype in clonally expanded antigen-specific CD8 T memory stem cells.

Journal of immunology (Baltimore, Md. : 1950) - 9 Feb 2026

Zhao Yanran, Samir Jerome, Keoshkerian Elizabeth, Li Hui, An Hongyan, Bull Rowena A, Luciani Fabio, Lloyd Andrew R

Abstract excerpt

Memory stem CD8+ T cells (TSCM) are a long-lived T-cell subset with stem cell-like properties, playing a key role in antiviral immunity. Despite their importance, comprehensive single-cell transcriptomic profiling of antigen-specific TSCM has not been previously conducted. In this study, an in vitro single-cell colony expansion protocol was used to investigate human CD8+ T-cell clones specific for cytomegalovirus...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41231761
DOI: 10.1093/jimmun/vkaf299

Genes

CCR7
CD27
IL7R
SELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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