Article

Pachytene piRNAs define a conserved program of meiotic gene regulation

2025-11-28

Abstract excerpt

<title>Abstract</title> <p>PIWI-interacting RNAs (piRNAs) safeguard genome integrity and fertility across animals and in humans1-3. In mammals, pre-pachytene piRNAs execute the ancestral program of transposon silencing, whereas a second, mammalian-specific class functions during meiosis4. These pachytene piRNAs are indispensable for spermatogenesis3, yet their sequence diversity, rapid evolution, and lack of obvi...

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Literature Corpus work: d10b7c6e-3faa-5617-afee-3c396c1a4822
DOI: 10.21203/rs.3.rs-8041753/v1

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