Article

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals

2018-02-07

Abstract excerpt

<h4>Summary</h4> In animals, piRNAs guide PIWI-proteins to silence transposons and regulate gene expression. The mechanisms for making piRNAs have been proposed to differ among cell types, tissues, and animals. Our data instead suggest a single model that explains piRNA production in most animals. piRNAs initiate piRNA production by guiding PIWI proteins to slice precursor transcripts. Next, PIWI proteins direct...

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Literature Corpus work: 08c21b0e-ec5e-5074-96b6-28d3683ae0bb
DOI: 10.1101/261545

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