A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements

Abstract excerpt

BACKGROUND: Piwi-interacting RNAs (piRNAs) are a recently discovered class of small non-coding RNAs whose best-understood function is to repress mobile element (ME) activity in animal germline. To date, nearly all piRNA studies have been conducted in model organisms and little is known about piRNA diversity, target specificity and biological function in human. RESULTS: Here we performed high-throughput sequencing...

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