Article
Variant PNLDC1, Defective piRNA Processing, and Azoospermia.
The New England journal of medicine - 19 Aug 2021
Nagirnaja Liina, Mørup Nina, Nielsen John E, Stakaitis Rytis, Golubickaite Ieva, Oud Manon S, Winge Sofia B, Carvalho Filipa, Aston Kenneth I, Khani Francesca, van der Heijden Godfried W, Marques C Joana, Skakkebaek Niels E, Rajpert-De Meyts Ewa, Schlegel Peter N, Jørgensen Niels, Veltman Joris A, Lopes Alexandra M, Conrad Donald F, Almstrup Kristian
Abstract excerpt
BACKGROUND: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ cells, where they regulate aberrant expression of transposable elements and postmeiotic gene expression. Critical to the processing of piRNAs is the protein poly(A)-specific RNase-like domain containing 1 (PNLDC1), which trims their 3' ends...
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