Article

Pachytene piRNAs define a conserved program of meiotic gene regulation

2025-11-06

Abstract excerpt

PIWI-interacting RNAs (piRNAs) safeguard genome integrity and fertility across animals and in humans 1-3 . In mammals, pre-pachytene piRNAs execute the ancestral program of transposon silencing, whereas a second, mammalian-specific class functions during meiosis 4 . These pachytene piRNAs are indispensable for spermatogenesis 3 , yet their sequence diversity, rapid evolution, and lack of obvious complementarity...

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Literature Corpus work: 0202339f-99c9-5f18-bd21-faf9b93477a1
DOI: 10.1101/2025.11.05.686807

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