Article

GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtype

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>Curative intervention of pancreatic ductal adenocarcinoma (PDAC) remains substantially precluded because cancer cells typically spread asymptomatically before diagnosis. We previously described <italic>GNA15</italic> ectopic expression in neoplastic and pre-neoplastic PDAC lesions. Here, we show that <italic>GNA15</italic>deletion in a mouse model of Kras-dependent PDAC reduced pancreat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0f1cbcc-44e0-57ac-9a23-543dd1a211fd
DOI: 10.21203/rs.3.rs-5186783/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtypeDOI 10.21203/rs.3.rs-5186783/v1Read

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDACSemantic proximity Read

A mucus production programme promotes classical pancreatic ductal adenocarcinomaSemantic proximity Read

Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in miceSemantic proximity Read

Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.Semantic proximity Read

Spatial transcriptomics identified mucin-specific O-glycosylation as a key pathway in pancreatic cancer development and a promising therapeutic targetSemantic proximity Read

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancerSemantic proximity Read

Stabilization of the classical phenotype upon integration of pancreatic cancer cells into the duodenal epithelium.Semantic proximity Read

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.Semantic proximity Read

Single-Cell Cross-Species Profiling identifies Conserved Transcriptional Networks in Early Pancreatic TumourigenesisSemantic proximity Read

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression.Semantic proximity Read

SPDEF promotes the classical subtype of pancreatic ductal adenocarcinomaSemantic proximity Read

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancerSemantic proximity Read