Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.

doi:10.1007/s00535-021-01846-4

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Article

Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.

Journal of gastroenterology - 1 Mar 2022

Kawabata Hidemasa, Ono Yusuke, Tamamura Nobue, Oyama Kyohei, Ueda Jun, Sato Hiroki, Takahashi Kenji, Taniue Kenzui, Okada Tetsuhiro, Fujibayashi Syugo, Hayashi Akihiro, Goto Takuma, Enomoto Katsuro, Konishi Hiroaki, Fujiya Mikihiro, Miyakawa Keita, Tanino Mishie, Nishikawa Yuji, Koga Daisuke, Watanabe Tsuyoshi, Maeda Chiho, Karasaki Hidenori, Liss Andrew S, Mizukami Yusuke, Okumura Toshikatsu

Abstract excerpt

BACKGROUND: Mutations in GNAS drive pancreatic tumorigenesis and frequently occur in intraductal papillary mucinous neoplasm (IPMN); however, their value as a therapeutic target is yet to be determined. This study aimed at evaluating the involvement of mutant GNAS in tumor aggressiveness in established pancreatic cancer. METHODS: CRISPR/Cas9-mediated GNAS R201H silencing was performed using human primary...

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PMID: 35018527
DOI: 10.1007/s00535-021-01846-4

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Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.PMID 35018527Read ↗

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