Article

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

2023-02-26

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with few available therapeutic options. Two transcriptional cancer cell states have been consistently reported in PDAC, with the basal-like/squamous phenotype displaying a more aggressive biological behavior. Genetic and epigenetic dysregulation of the axon guidance pathway are common in PDAC, yet our understanding of its biological relevance is limited....

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Literature Corpus work: e6ad2d0e-5ebe-5498-bd3b-47bbef8c29be
DOI: 10.1101/2023.02.25.529923

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