Article
Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.
The Journal of clinical investigation - 1 Nov 2023
Wang Xiaobo, Istvanffy Rouzanna, Ye Linhan, Teller Steffen, Laschinger Melanie, Diakopoulos Kalliope N, Görgülü Kıvanç, Li Qiaolin, Ren Lei, Jäger Carsten, Steiger Katja, Muckenhuber Alexander, Vilne Baiba, Çifcibaşı Kaan, Reyes Carmen Mota, Yurteri Ümmügülsüm, Kießler Maximilian, Gürçınar Ibrahim Halil, Sugden Maya, Yıldızhan Saliha Elif, Sezerman Osman Uğur, Çilingir Sümeyye, Süyen Güldal, Reichert Maximilian, Schmid Roland M, Bärthel Stefanie, Oellinger Rupert, Krüger Achim, Rad Roland, Saur Dieter, Algül Hana, Friess Helmut, Lesina Marina, Ceyhan Güralp Onur, Demir Ihsan Ekin
Abstract excerpt
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC, comprising 295 different...
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