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Article

In silico analysis of mutations near S1/S2 cleavage site in SARS-CoV-2 spike protein reveals increased propensity of glycosylation in Omicron strain.

Journal of medical virology - 1 Sept 2022

Beaudoin Christopher A, Pandurangan Arun P, Kim So Yeon, Hamaia Samir W, Huang Christopher L-H, Blundell Tom L, Vedithi Sundeep Chaitanya, Jackson Antony P

Abstract excerpt

Cleavage of the severe respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein has been demonstrated to contribute to viral-cell fusion and syncytia formation. Studies have shown that variants of concern (VOC) and variants of interest (VOI) show differing membrane fusion capacity. Mutations near cleavage motifs, such as the S1/S2 and S2' sites, may alter interactions with host proteases and, thus, the...

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PMID: 35575289
DOI: 10.1002/jmv.27845
PMCID: PMC9348480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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