Article

Conserved role of spike S2 domain N-glycosylation across beta-coronavirus family

2024-09-05

Abstract excerpt

Besides acting as an immunological shield, the N-glycans of SARS-CoV-2 are also critical for viral life cycle. As the S2 subunit of spike is highly conserved across beta-coronaviruses, we determined the functional significance of the five ‘stem N-glycans’ located in S2 between N1098-N1194. Studies were performed with 31 Asn-to-Gln mutants, beta-coronavirus virus-like particles and single-cycle viral replicons. Del...

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Literature Corpus work: b2c8fca3-d155-5f25-b984-8a373aee54d1
DOI: 10.1101/2024.09.05.611372

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