Article

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

2021-04-06

Abstract excerpt

<h4>Summary</h4> The trimeric spike protein (S) mediates host-cell entry and membrane fusion of SARS-CoV-2. S protein is highly glycosylated, whereas its O-glycosylation is still poorly understood. Herein, we site-specifically examine the O-glycosylation of S protein through a mass spectrometric approach with HCD-triggered-ETD model. We identify 15 high-confidence O-glycosites and at least 10 distinct O-glycan st...

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Literature Corpus work: 7445aa89-db03-5a88-8359-dfec7b9a5036
DOI: 10.1101/2021.04.06.438614

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Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric StructureDOI 10.1101/2021.04.06.438614Read

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