Article

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

2022-09-15

Abstract excerpt

<h4>ABSTRACT</h4> The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in major variants of concern including Alpha, Delta and Omicron. Besides furin, spike proteins from these variants appear to rely on other proteases f...

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Literature Corpus work: 038f28af-e293-544c-bed3-843456ea9398
DOI: 10.1101/2022.09.15.508093

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