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Article

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Millet Jean Kaoru, Whittaker Gary R

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) protein is the main determinant of viral entry, and although it was previously shown that MERS-CoV S can be activated by various proteases, the details of the mechanisms of proteolytic activation of fusion are still incompletely characterized....

Topics

Animals
Cell Line, Tumor
Chlorocebus aethiops
Computational Biology
Furin
Gene Silencing
Genetic Predisposition to Disease
HEK293 Cells
Humans
Middle East Respiratory Syndrome Coronavirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Hydrolases

RNA, Small Interfering

Receptors, Virus

Spike Glycoprotein, Coronavirus

Time Factors

Vero Cells

Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 25288733
DOI: 10.1073/pnas.1407087111
PMCID: PMC4210292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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